NHPI-catalyzed electrochemical C–H alkylation of indoles with alcohols to access di(indolyl)methanes <i>via</i> radical coupling
Bingwen Li, Hongyun Qin, Kelu Yan, Jing Ma, Jianjing Yang, Jiangwei Wen
Abstract
The present indirect electrochemically mediated radical protocol outperforms the traditional Friedel–Crafts route with a broad substrate scope and functional group tolerance, as well as facile gram-scale synthesis without metal contamination.
Topics & Concepts
ChemistryCatalysisAlkylationSubstrate (aquarium)ElectrochemistryFunctional groupFriedel–Crafts reactionCombinatorial chemistryIndole testOrganic chemistryGeologyPolymerOceanographyElectrodePhysical chemistryCatalytic C–H Functionalization MethodsRadical Photochemical ReactionsSynthesis of Indole Derivatives