PD-1 blockade therapy promotes infiltration of tumor-attacking exhausted T cell clonotypes
Joji Nagasaki, Takashi Inozume, Nicolas Sax, Ryo Ariyasu, Masakazu Ishikawa, Kazuo Yamashita, Masahito Kawazu, Toshihide Ueno, Takuma Irie, Etsuko Tanji, Takao Morinaga, Akiko Honobe, Takehiro Ohnuma, Mitsuru Yoshino, Takekazu Iwata, Katsushige Kawase, Keita Sasaki, Toyoyuki Hanazawa, Vitaly Kochin, Tatsuyoshi Kawamura, Hiroyuki Matsue, Masayuki Hino, Hiroyuki Mano, Yutaka Suzuki, Hiroyoshi Nishikawa, Yosuke Togashi
Abstract
clonotypes, mainly from TDLNs.
Topics & Concepts
BlockadeBystander effectTumor microenvironmentT cellImmunologyLymphBiologyCancer researchTumor-infiltrating lymphocytesInfiltration (HVAC)MedicineImmune systemImmunotherapyPathologyReceptorGeneticsThermodynamicsPhysicsCancer Immunotherapy and BiomarkersCAR-T cell therapy researchSingle-cell and spatial transcriptomics