PPARγ Regulates Macrophage Polarization by Inhibiting the JAK/STAT Pathway and Attenuates Myocardial Ischemia/Reperfusion Injury In Vivo
Shengnan Wang, Yinlian Cai, Rongsheng Bu, Yaoguo Wang, Qingfan Lin, Youfang Chen, Chunchun Wu
Topics & Concepts
FibrosisProinflammatory cytokineMacrophage polarizationApoptosisTUNEL assayIn vivoBlotPeroxisome proliferator-activated receptorReperfusion injuryp38 mitogen-activated protein kinasesMedicineM2 MacrophageMacrophageSignal transductionIschemiaCancer researchInflammationChemistryInternal medicineBiologyReceptorCell biologyIn vitroMAPK/ERK pathwayBiochemistryBiotechnologyGeneCardiac Ischemia and ReperfusionCardiovascular Function and Risk FactorsCardiac Fibrosis and Remodeling