The potential role of nucleophosmin (NPM1) in the development of cancer
Fateme Karimi Dermani, Saeideh Gholamzadeh Khoei, Saeid Afshar, Razieh Amini
Abstract
Nucleophosmin (NPM1) is a well-known nucleocytoplasmic shuttling protein that performs several cellular functions such as ribosome biogenesis, chromatin remodeling, genomic stability, cell cycle progression, and apoptosis. NPM1 has been identified to be necessary for normal cellular functions, and its altered regulation by overexpression, mutation, translocation, loss of function, or sporadic deletion can lead to cancer and tumorigenesis. In this review, we focus on the gene and protein structure of NPM1 and its physiological roles. Finally, we discuss the association of NPM1 with various types of cancer including solid tumors and leukemia.
Topics & Concepts
NucleophosminNPM1Ribosome biogenesisCarcinogenesisBiologyChromatin remodelingCell biologyChromatinCancer researchGenome instabilityMutationGene mutationCancerDNA damageGeneGeneticsRibosomeDNARNAKaryotypeChromosomeAcute Myeloid Leukemia ResearchRNA modifications and cancerNuclear Structure and Function