Vitamin D and the Kidney: Two Players, One Console
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Abstract
Vitamin D belongs to the group of liposoluble steroids mainly involved in bone metabolism by modulating calcium and phosphorus absorption or reabsorption at various levels, as well as parathyroid hormone production. Recent evidence has shown the extra-bone effects of vitamin D, including glucose homeostasis, cardiovascular protection, and anti-inflammatory and antiproliferative effects. This narrative review provides an overall view of vitamin D's role in different settings, with a special focus on chronic kidney disease and kidney transplant.