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Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway

Lijie Lv, Kunlin Song, Yijie Xiao, Jia Zheng, Wei Zhang, Linfeng Li, Yue Wei, Hao Chen, Yi He, Zufeng Guo, Shenyou Nie

2024Bioorganic Chemistry13 citationsDOI

Topics & Concepts

PI3K/AKT/mTOR pathwayChemistryIndole testProtein kinase BTotal synthesisRational designDrug designPharmacologyCancer researchSignal transductionStereochemistryBiochemistryMedicineBiologyGeneticsSynthesis and bioactivity of alkaloidsCancer therapeutics and mechanismsSynthesis and Biological Activity
Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway | Litcius