A low-intensity focused ultrasound-assisted nanocomposite for advanced triple cancer therapy: local chemotherapy, therapeutic extracellular vesicles and combined immunotherapy
Mixiao Tan, Yuli Chen, Yuan Guo, Chao Yang, Mingzhu Liu, Dan Guo, Zhigang Wang, Yang Cao, Haitao Ran
Abstract
promotes M1-like macrophage polarization, reversing immunosuppressive TME, and locally released chemotherapeutics potentiate antitumor immune response; both facilitate PD1/PD-L1 checkpoint blockade combined immunotherapy. Taken together, therapies of CT-EVs-IT assisted by LIFU contribute to achieve amplified antitumor benefits.
Topics & Concepts
ImmunotherapyChemotherapyMedicineExtracellular vesiclesCancer researchNanocompositeHigh-intensity focused ultrasoundCancer immunotherapyCancerUltrasoundInternal medicineMaterials scienceNanotechnologyRadiologyBiologyCell biologyNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryExtracellular vesicles in disease