Purmorphamine, a Smo-Shh/Gli Activator, Promotes Sonic Hedgehog-Mediated Neurogenesis and Restores Behavioural and Neurochemical Deficits in Experimental Model of Multiple Sclerosis
Aradhana Prajapati, Sidharth Mehan, Zuber Khan, Swesha Chhabra, Ghanshyam Das Gupta
Topics & Concepts
Multiple sclerosisNeuroprotectionMyelin basic proteinSonic hedgehogMedicineExperimental autoimmune encephalomyelitisPharmacologyInternal medicineEndocrinologyMyelinNeuroscienceChemistryCentral nervous systemBiologyImmunologyBiochemistrySignal transductionHedgehog Signaling Pathway StudiesNatural Compounds in Disease TreatmentNeurogenesis and neuroplasticity mechanisms