Synthesis of new class of non-sulfonamide bis-benzimidazoles as antitumor agents by inhibiting carbonic anhydrase-IX enzyme
Shakeel Ahmad Khan, Zarbad Shah, Syed Raza Shah, Majid Khan, Sobia Ahsan Halim, Ajmal Khan, Javid Hussain, Magda H. Abdellattif, Bashir Ahmad, Ahmed Al‐Harrasi
Topics & Concepts
ChemistryCarbonic anhydraseEnzymeBenzimidazoleAcetazolamideIn vivoIn vitroCarbonic Anhydrase IDocking (animal)ImidazoleCarbonic anhydrase IIIC50Active siteBiochemistryCell cultureStereochemistryBiologyBiotechnologyNursingPhysiologyMedicineOrganic chemistryGeneticsEnzyme function and inhibitionCholinesterase and Neurodegenerative DiseasesSynthesis and Catalytic Reactions