Long non-coding RNA XIST: a novel oncogene in multiple cancers
Jun Yang, Manlong Qi, Xiang Fei, Xia Wang, Kefeng Wang
Abstract
Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions as an oncogene. XIST is involved in multiple aspects of carcinogenesis, including tumor onset, progression, and prognosis. In our review, we collected and analyzed the recent studies on the impact of XIST in human tumor development. The multilevel molecular functions of XIST in human tumors are comprehensively reviewed to clarify the pathologic mechanisms and to offer a novel direction for further study.
Topics & Concepts
XISTLong non-coding RNAOncogeneBiologyRNAX-inactivationHuman geneticsCarcinogenesisNon-coding RNAMolecular medicineCancer researchGeneticsGeneComputational biologyX chromosomeCell cycleCancer-related molecular mechanisms researchRNA Research and SplicingCircular RNAs in diseases