The role of the milling environment on the copper-catalysed mechanochemical synthesis of tolbutamide
Kathleen Floyd, Lori Gonnet, Tomislav Friščić, James D. Batteas
Abstract
Under controlled atmospheres the mechanochemical synthesis of tolbutamide is catalysed by Cu( ii ), with CuCl acting as a pre-catalyst, activated via aerobic oxidation under milling. Use of aluminum jars results in mechanoinhibition of this process.
Topics & Concepts
TolbutamideCopperMetallurgyMaterials scienceChemistryBiologyBiotechnologyInsulinCrystallography and molecular interactionsPhenothiazines and Benzothiazines Synthesis and ActivitiesChemical Synthesis and Analysis