Neuron-derived neurotensin promotes pancreatic cancer invasiveness and gemcitabine resistance via the NTSR1/Akt pathway
Yu‐Hsuan Hung
Abstract
. NTS boosted gemcitabine resistance via NTSR1 in pancreatic cancer. Our results suggest that neural cell-secreted NTS plays an important role in promoting PDAC.
Topics & Concepts
Pancreatic cancerCancer researchGemcitabinePI3K/AKT/mTOR pathwayAdenocarcinomaBiologyCancerNeurotensin receptorNeurotensinInternal medicineReceptorMedicineSignal transductionNeuropeptideCell biologyNeuropeptides and Animal PhysiologyCancer, Stress, Anesthesia, and Immune ResponseNeuroendocrine Tumor Research Advances