Copper-assisted trifluoromethylthiolation/radical cascade cyclization of alkynes to construct SCF<sub>3</sub>-containing dioxodibenzothiazepines
Xiaoyu Chen, Congcong Pei, Bo Liu, Jingya Li, Dapeng Zou, Yangjie Wu, Yusheng Wu
Abstract
as the trifluoromethylthiolating reagent has been disclosed. This transformation provides an opportunity to construct a series of potential medicinally valuable trifluoromethylthio-substituted dioxodibenzothiazepines with wide functional group compatibility. This protocol opens up a new avenue for the construction of useful trifluoromethylthiolated seven-membered N-heterocycles.
Topics & Concepts
ReagentCascadeChemistryRadical cyclizationCombinatorial chemistryConstruct (python library)Compatibility (geochemistry)Functional groupStereochemistryOrganic chemistryComputer scienceChemical engineeringChromatographyEngineeringPolymerProgramming languageFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods