Rare germline variants in the AXIN2 gene in families with colonic polyposis and colorectal cancer
James Chan, Mark Clendenning, Sharelle Joseland, Peter Georgeson, Khalid Mahmood, Romy Walker, Julia Como, Jihoon E. Joo, Susan Preston, Ryan Hutchinson, Bernard J. Pope, Andrew J. Metz, Catherine Beard, Rebecca Purvis, Julie Arnold, Varnika Vijay, Galina Konycheva, Nathan Atkinson, Susan Parry, Mark A. Jenkins, Finlay Macrae, Christophe Rosty, Ingrid Winship, Daniel D. Buchanan
Topics & Concepts
AXIN2GermlineColorectal cancerGermline mutationLoss of heterozygosityFamilial adenomatous polyposisProbandMUTYHGeneticsBiologyMedicineCancerMutationGeneAlleleWnt signaling pathwayGenetic factors in colorectal cancerWnt/β-catenin signaling in development and cancerdental development and anomalies