K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap
Gabriëlle B. A. van Tilburg, A.G. Murachelli, Alexander Fish, Gerbrand J. van der Heden van Noort, Huib Ovaa, Titia K. Sixma
Topics & Concepts
Deubiquitinating enzymeUbiquitinLysineChemistryCysteineCovalent bondConjugated systemStereochemistrySide chainCombinatorial chemistryEnzymeMechanism (biology)BiochemistryBiophysicsAmino acidBiologyPolymerGeneOrganic chemistryPhilosophyEpistemologyUbiquitin and proteasome pathwaysCancer-related Molecular PathwaysMitochondrial Function and Pathology