Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease
Yiyi Zhang, Jacqueline S. Dron, Brandon K. Bellows, Amit V. Khera, Junxiu Liu, Pallavi Balte, Elizabeth C. Oelsner, Sami S. Amr, Matthew S. Lebo, Anna Nagy, Gina M. Peloso, Pradeep Natarajan, Jerome I. Rotter, Cristen J. Willer, Eric Boerwinkle, Christie M. Ballantyne, Pamela L. Lutsey, Myriam Fornage, Donald M. Lloyd‐Jones, Lifang Hou, Bruce M. Psaty, Joshua C. Bis, James S. Floyd, Ramachandran S. Vasan, Nancy L. Heard‐Costa, April P. Carson, Michael E. Hall, Stephen S. Rich, Xiuqing Guo, Dhruv S. Kazi, Sarah D. de Ferranti, Andrew E. Moran
Abstract
amilial hypercholesterolemia (FH) is a genetic disorder characterized by markedly elevated low-density lipoprotein cholesterol (LDL-C) from birth that often causes premature coronary heart disease (CHD). 1 FH can be diagnosed with established clinical criteria such as the Dutch Lipid Clinic Network criteria with or without genetic testing.