AUF1 gene transfer increases exercise performance and improves skeletal muscle deficit in adult mice
Dounia Abbadi, John J. Andrews, Olga Katsara, Robert J. Schneider
Abstract
mRNA, which is strongly reduced in adult muscle in the absence of AUF1 supplementation. Skeletal muscle-specific gene transfer of AUF1 therefore restores muscle mass, increases exercise endurance, and may provide a therapeutic strategy for age-related muscle loss.
Topics & Concepts
Skeletal muscleGene transferMedicinePhysical medicine and rehabilitationBiologyInternal medicineGeneBiochemistryAdipose Tissue and MetabolismMuscle Physiology and DisordersMuscle metabolism and nutrition