Base-tuned selective 1,2-dichloromethylhydroxylation and 1,2-peroxyhydroxylation of 1,3-dienes <i>via</i> a tandem radical process
Jiantao Zhang, Weiming Zhu, Peng Zhou, Cui Chen, Weibing Liu
Abstract
was employed as the base, the key intermediate α-amino radical could not be formed; therefore, 1,2-peroxyhydroxylation products were obtained instead. This protocol provides an effective and functional group tolerant strategy for diene 1,2-difunctionalization, thus providing great potential for further functionalization and modification of synthetic molecules.
Topics & Concepts
TandemChemistryBase (topology)Process (computing)Combinatorial chemistryComputer scienceMaterials scienceMathematicsOperating systemMathematical analysisComposite materialOxidative Organic Chemistry ReactionsChemical Synthesis and ReactionsCatalytic C–H Functionalization Methods