Molecular Mechanism of Runx2-Dependent Bone Development.
Toshihisa Komori
Abstract
. Cbfb, which is a co-transcription factor that forms a heterodimer with Runx2, enhances DNA binding of Runx2 and stabilizes Runx2 protein by inhibiting its ubiquitination. Thus, Runx2/Cbfb regulates the proliferation and differentiation of chondrocytes and osteoblast-lineage cells by activating multiple signaling pathways and via their reciprocal regulation.
Topics & Concepts
RUNX2Indian hedgehogOsteoblastChondrocyteEndochondral ossificationCell biologyWnt signaling pathwayMesenchymal stem cellCyclopamineBiologyBone morphogenetic protein 2Transcription factorCellular differentiationChemistrySignal transductionCartilageHedgehog signaling pathwayAnatomyGeneticsGeneIn vitroBone Metabolism and DiseasesInflammatory mediators and NSAID effectsTGF-β signaling in diseases