Co-inhibition of BET proteins and PI3Kα triggers mitochondrial apoptosis in rhabdomyosarcoma cells
Cathinka Boedicker, Michelle Hussong, Christina Grimm, Nadezda Dolgikh, Michael T. Meister, Julius C. Enßle, Marek Wanior, Stefan Knapp, Michal R. Schweiger, Simone Fulda
Topics & Concepts
BromodomainBiologyApoptosisBcl-2 familyBcl-xLBET inhibitorCancer researchPI3K/AKT/mTOR pathwayGene silencingPumaGene knockdownTranscription factorCell biologyProgrammed cell deathInhibitor of apoptosisMolecular biologyEpigeneticsGeneGeneticsProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways