Design, synthesis, and antitumor evaluation of new pyridazinone scaffolds as dual EGFR/VEGFR-2 kinase inhibitors and apoptotic cells inducers
Sara Y Ewieda, Eman Ahmed, Nirvana A. Gohar, Ibrahim Sa, Marwa A. Essa, Mohamed T. M. Nemr
Topics & Concepts
ChemistryErlotinibSorafenibKinasePharmacologyCell cultureDoxorubicinCytotoxicityApoptosisCell growthCell cycle checkpointCell cycleCytotoxic T cellCancer cellCancer researchCellBiochemistryEGFR inhibitorsLiver cancerInhibitory postsynaptic potentialProtein kinase BHER2/EGFR in Cancer ResearchCancer Mechanisms and TherapySynthesis and biological activity