The Effect of Oral Iron Supplementation on Gut Microbial Composition: a Secondary Analysis of a Double-Blind, Randomized Controlled Trial among Cambodian Women of Reproductive Age
Emma Finlayson‐Trick, Jacob T. Nearing, Jordie A. J. Fischer, Yvonne Ma, Siyun Wang, Hou Krouen, David A. Goldfarb, Crystal D Karakochuk
Abstract
, and Escherichia coli. Using qPCR for additional analysis, we were able to detect genes associated with enteropathogenic E. coli, a type of diarrheagenic E. coli known to be present around the world, including water systems in Cambodia. The current WHO guidelines recommend blanket (untargeted) iron supplementation for Cambodian WRA despite a lack of studies in this population examining iron's effect on the gut microbiome. This study can facilitate future research that may inform evidence-based global practice and policy.
Topics & Concepts
Composition (language)PhysiologyDouble blindDemographyRandomized controlled trialMedicineBiologyInternal medicinePlaceboSociologyPathologyPhilosophyAlternative medicineLinguisticsNutritional Studies and DietChild Nutrition and Water AccessDiet and metabolism studies