Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development
Gabriela Veronica Pinget, Jian Tan, Duan Ni, Jemma Taitz, C. Daïen, Julie Mielle, Robert J. Moore, Dragana Stanley, Stephen J. Simpson, Nicholas J. C. King, Laurence Macia
Abstract
macrophages ex vivo, while disrupted gut homeostasis primes IMQ-pso mice for more severe colitis with dextran sulfate sodium (DSS) challenge. These results demonstrate that changes in the gut environment in psoriasis lead to greater susceptibility to IBD in mice, suggesting a two-hit requirement, that is, psoriasis-induced altered gut homeostasis and a secondary environmental challenge. This may explain the increased prevalence of IBD in patients with psoriasis.
Topics & Concepts
PsoriasisDysbiosisImmunologyGut floraColitisImiquimodInflammatory bowel diseaseHomeostasisCytokineUlcerative colitisBiologyMedicineDiseaseInternal medicinePsoriasis: Treatment and PathogenesisInflammatory Bowel DiseaseIL-33, ST2, and ILC Pathways