Synthesis and bioactive evaluation of <i>N</i>-((1-methyl-1<i>H</i>-indol-3-yl)methyl)-<i>N</i>-(3,4,5-trimethoxyphenyl)acetamide derivatives as agents for inhibiting tubulin polymerization
Aonan Ren, Wanxing Wei, Zhengcheng Liang, Min Zhou, Taoyuan Liang, Ning Zang
Abstract
Based on the inhibitory effect of CA-4 analogues and indoles on tubulin polymerization, we designed and synthesized a series of N -((1-methyl-1 H -indol-3-yl)methyl)-2-(1 H -pyrazol-1-yl or triazolyl)- N -(3,4,5-trimethoxyphenyl)acetamides.
Topics & Concepts
AcetamideChemistryTubulinStereochemistryCombinatorial chemistryMicrotubuleOrganic chemistryBiologyCell biologySynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications