Novel SmartReservoirs for hydrogel-forming microneedles to improve the transdermal delivery of rifampicin
Abraham M. Abraham, Qonita Kurnia Anjani, Masoud Adhami, Aaron R. J. Hutton, Eneko Larrañeta, Ryan F. Donnelly
Abstract
SmartReservoirs (SRs) are novel drug-reservoirs for hydrogel-forming microneedles (HF-MNs). SRs improved rifampicin solubility and diffusion through the HF-matrix, thereby enhancing the transdermal permeation of the poorly soluble antibiotic.
Topics & Concepts
TransdermalMaterials sciencePermeationSolubilityRifampicinDrug deliveryDiffusionBiomedical engineeringNanotechnologyPharmacologyAntibioticsChemistryOrganic chemistryMedicinePhysicsThermodynamicsMembraneBiochemistryAdvancements in Transdermal Drug DeliveryAdvanced Drug Delivery SystemsDermatology and Skin Diseases