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DDX39B protects against sorafenib-induced ferroptosis by facilitating the splicing and cytoplasmic export of GPX4 pre-mRNA in hepatocellular carcinoma

Qin Li, Hang Yuan, Gang Zhao, Deqiong Ou, Jie Zhang, Liang Li, Siqi Li, Tianyu Feng, Rui Gu, Qiming Kou, Qijing Wang, Shan Li, Guanru Wang, Minghui Zhao, Huayang Yu, Jie Qu, Ping Lin, Kai Li, Huayang Yu, Jie Qu, Ping Lin, Kai Li

2024Biochemical Pharmacology13 citationsDOI

Topics & Concepts

SorafenibHepatocellular carcinomaCancer researchGPX4Cancer cellProgrammed cell deathChemistryLiver cancerDownregulation and upregulationCellApoptosisCancerBiologyCell biologyBiochemistryGlutathioneGeneEnzymeGeneticsGlutathione peroxidaseFerroptosis and cancer prognosisRNA modifications and cancerRNA Research and Splicing
DDX39B protects against sorafenib-induced ferroptosis by facilitating the splicing and cytoplasmic export of GPX4 pre-mRNA in hepatocellular carcinoma | Litcius