Zebrafish (Danio rerio) as an ecotoxicological model for Nanomaterial induced toxicity profiling
Suresh K. Verma, Aditya Nandi, Adrija Sinha, Paritosh Patel, Ealisha Jha, Swabhiman Mohanty, Pritam Kumar Panda, Rajeev Ahuja, Yogendra Kumar Mishra, Mrutyunjay Suar
Abstract
<img src=” https://s3.amazonaws.com/production.scholastica/article/21978/large/graphical_abstract300.jpg?1616953934”> With the advancement of technologies, the evolution of nanoscience is occurring at a rapid pace. The demand for nanomaterials in various industries has increased. However, they may pose an increased risk upon exposure to living organisms, demanding toxicological studies. Alt-hough risk assessment of nanomaterials is a challenge due to their varieties in sizes and variabil-ity in properties, different methodologies of toxicity screenings have been used successfully to evaluate the potential risks. Although nanotechnology has contributed to technology develop-ment and well-being, information in these fields is still incomplete. Fortunately, those areas are under continuous research, and there are increasing experimental efforts in determining the envi-ronmental effects on humans exposed to nanoparticles. Since the field of nanotechnology is continuously expanding, we need medium- to high throughput nanotoxicity screenings to deter-mine any potential risks caused by nanomaterials. Zebrafish, a well-established model for mammalian research, have advantages when used in these toxicity screenings. This review de-scribes various kinds of toxicities induced in zebrafish embryos by different kinds of nanopar-ticles. A significant number of experimental data from toxicological studies are also presented that determine nanomaterials’ effects, which can be modulated or further mitigated to create a positive impact on living organisms.