Degradation-Dependent Controlled Delivery of Doxorubicin by Glyoxal Cross-Linked Magnetic and Porous Chitosan Microspheres
Nechikkottil S. Sumitha, Prabha Prakash, Balagopal N. Nair, G. S. Sailaja
Abstract
swelling and degradation results demonstrate that a swelling plateau of GMS is reached at 24 h, while degradation can be modulated to begin at 96-120 h by formulating the cross-linked network using glyoxal. MTT assay, live/dead staining, and F-actin staining (actin/DAPI) validated the cytocompatibility of GMS, which further assured good drug loading capacity (35.8%). The release mechanism has two stages, initiated by diffusion-inspired release of DOX through the swollen polymer network (72 h), which is followed by a disintegration-tuned release profile (>96 h) conferring GMS a potential candidate for DOX delivery.
Topics & Concepts
ChitosanSwellingGlyoxalSuperparamagnetismDrug deliveryChemistryDegradation (telecommunications)EmulsionDrug carrierNuclear chemistryDoxorubicinMaterials scienceChemical engineeringNanotechnologyBiochemistryOrganic chemistryComposite materialSurgeryMagnetizationMagnetic fieldQuantum mechanicsPhysicsTelecommunicationsMedicineComputer scienceChemotherapyEngineeringNanoparticle-Based Drug DeliveryCarbon and Quantum Dots ApplicationsGraphene and Nanomaterials Applications