Gold brocade coated CoFe PBA with enhanced peroxidase-like activity for a chemiluminescent imaging immunoassay
Ling Li, Qingwen Chen, Feng Shi, Jiayu Wu, Lingfeng Min, Juan Li, Zhanjun Yang
Abstract
Traditional chemiluminescence (CL) imaging immunoassays usually rely on natural enzymes as catalytic probes, which has hampered their extensive application due to the susceptibility to inactivation of natural enzymes. In response, a gold brocade coated CoFe Prussian blue analogue (CoFe PBA@Au brocade) with enhanced peroxidase-like activity was synthesized and utilized as a powerful label probe for constructing a highly sensitive CL imaging immunosensor targeting disease biomarkers with excellent performance. This research offers a universal strategy for enhancing the sensitivity of CL imaging immunoassays and further expands the application of PBA nanozymes.
Topics & Concepts
ChemiluminescenceImmunoassayPeroxidaseChemistryLuminescent MeasurementsNuclear chemistryChromatographyNanotechnologyMaterials scienceEnzymeBiochemistryMedicineOptoelectronicsLuminescenceAntibodyImmunologyAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesElectrochemical sensors and biosensors