Transition metal-free approach for late-stage benzylic C(sp<sup>3</sup>)–H etherifications and esterifications
Yu Zhang, Prakash Kumar Sahoo, Peng Ren, Yuman Qin, Robin Cauwenbergh, Philippe Nimmegeers, Gandhi Sivaraman, Steven Van Passel, Andrea Guidetti, Shoubhik Das
Abstract
)-H bonds using alcohols and carboxylic acids as the nucleophiles. This straightforward and general route has provided various benzylic ethers and esters, including twelve pharmaceutically relevant compounds.
Topics & Concepts
RegioselectivityChemistryTransition metalNucleophileOrganic chemistrySurface modificationMetalMedicinal chemistryCatalysisPhysical chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsCyclopropane Reaction Mechanisms