Repurposing of camptothecin: An esterase-activatable prodrug delivered by a self-emulsifying formulation that improves efficacy in colorectal cancer
Tao Fang, Zhijian Ye, Xiaona Chen, Yuchen Wang, Jianqin Wan, Hangxiang Wang
Topics & Concepts
ProdrugCamptothecinPharmacologyPharmacokineticsIrinotecanDrugActive metaboliteIn vivoChemistryColorectal cancerSN-38BioavailabilityPharmaceutical formulationMedicineCancerBiochemistryBiologyInternal medicineBiotechnologyNanoparticle-Based Drug DeliveryCancer therapeutics and mechanismsNanoplatforms for cancer theranostics