Tin disulfide–graphene oxide-β-cyclodextrin mediated electro-oxidation of melatonin hormone: an efficient platform for electrochemical sensing
Xinrui Liu, Rajalakshmi Sakthivel, Yu‐Cheng Chen, Ning Chang, Udesh Dhawan, Yunqian Li, Gang Zhao, Ching‐Po Lin, Ren‐Jei Chung
Abstract
Here, we have developed an electrochemical sensor based on integrated 2D materials including tin disulfide (SnS2) nanoflakes, graphene oxide (GO), and β-cyclodextrin (β-CD) forming a ternary nanocomposite decorated on a screen-printed electrode (SPE) for the electrochemical detection of melatonin. Hydrothermally synthesized SnS2 was mixed with GO/β-CD to prepare the ternary composite via an ultra-sonication process. The nanocomposite was characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), and field emission transmission electron microscopy (FEG-TEM). The electrochemical performance of the modified electrode was investigated using cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and differential pulse voltammetry (DPV). The electrochemical sensor exhibited a linearity range from 1 nM to 100 μM with the lowest detection limit of 0.17 nM. The sensor was successfully applied for the detection of melatonin in commercial drugs and human saliva, which showed a consistent result with the Enzyme-Linked Immuno-Sorbent Assay (ELISA).