Measuring and estimating insulin resistance in clinical and research settings
Amalia Gastaldelli
Abstract
The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.
Topics & Concepts
Insulin resistanceMedicineGold standard (test)ReproducibilityCutoffAdipose tissueClampGlucose tolerance testInternal medicineInsulinGlucose clamp techniqueEndocrinologyPancreatic hormoneStatisticsComputer scienceMathematicsPhysicsQuantum mechanicsComputer visionClampingMetabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and LipoproteinsAdipose Tissue and Metabolism