Electrochemical Selenation/Cyclization of Quinones: A Rapid, Green and Efficient Access to Functionalized Trypanocidal and Antitumor Compounds
Ammar Kharma, Claus Jacob, Ícaro A. O. Bozzi, Guilherme A. M. Jardim, Antônio L. Braga, Kelly Salomão, Claudia C. Gatto, Maria Francilene Souza Silva, Cláudia Pessoa, Maximilian Stangier, Lutz Ackermann, Eufrânio N. da Silva Júnior
Abstract
Electrochemical selenation in undivided electrochemical cells allows the preparation of selenium‐containing naphthoquinones. The rapid, green and efficient protocol avoids chemical oxidants and enables the synthesis of target molecules in a fast and reliable way. This strategy provides and efficient and general method for the synthesis of quinoidal compounds with activity against five cancer cell lines and Trypanosoma cruzi , the parasite that causes Chagas disease.
Topics & Concepts
ChemistryElectrochemistryTrypanosoma cruziCombinatorial chemistryChemical synthesisSeleniumCancer cell linesMoleculeOrganic chemistryCancer cellIn vitroBiochemistryCancerParasite hostingMedicineElectrodePhysical chemistryComputer scienceWorld Wide WebInternal medicineSynthesis and Biological EvaluationAdvanced battery technologies researchRadical Photochemical Reactions