A <i>Vibrio</i> T6SS-Mediated Lethality in an Aquatic Animal Model
Hadar Cohen, Chaya Mushka Fridman, Motti Gerlic, Dor Salomon
Abstract
and the human illnesses associated with them. Since vibrios often share virulence traits horizontally, a better understanding of their virulence potential and determinants can prepare us for new emerging pathogens. In this work, we showed that a toxin delivery system found in various vibrios mediates lethality in an aquatic animal. Taken together with previous reports showing that the same system induces inflammasome-mediated cell death in mammalian phagocytic cells, our findings suggest that this delivery system and its associated toxins may contribute to the emergence of pathogenic strains.
Topics & Concepts
VirulenceBiologyMicrobiologyEffectorVibrioLethalityBrine shrimpType VI secretion systemPathogenic bacteriaInflammasomeSecretionBacteriaGeneGeneticsCell biologyEcologyBiochemistryReceptorVibrio bacteria research studiesAquaculture disease management and microbiotaSalmonella and Campylobacter epidemiology