ARID1B Deficiency Leads to Impaired DNA Damage Response and Activated cGAS-STING Pathway in Non-Small Cell Lung Cancer
Guangsheng Zhu, Jinghao Liu, Li Y, Hua Huang, Chen Chen, Di Wu, Peijun Cao, Lianchun Su, Yanan Wang, Hongbing Zhang, Hongyu Liu, Jun Chen
Abstract
ARID1B mutation may predict improved response to ICIs in NSCLC patients. ARID1B mutation leads to impaired DNA damage response and repair, altered chromatin accessibility, and cGAS-STING pathway activation. These findings provide insights into ARID1B's biology and therapeutic implications in lung cancer, highlighting its potential as a target for precision medicine and immunotherapy. Further validation and clinical studies are warranted.
Topics & Concepts
Gene knockdownDNA damageChromatin remodelingCancer researchImmune systemMutationLung cancerChromatinBiologyDNA repairCancerGeneImmunologyDNAMedicineGeneticsOncologyCancer Mechanisms and TherapyChromatin Remodeling and Cancerinterferon and immune responses