Macrophage membrane- and cRGD-functionalized thermosensitive liposomes combined with CPP to realize precise siRNA delivery into tumor cells
Jingxue Nai, Jinbang Zhang, Jiaxin Li, Hui Li, Yang Yang, Meiyan Yang, Yuli Wang, Wei Gong, Zhiping Li, Lin Li, Chunsheng Gao
Abstract
and in mice, less uptake by the reticuloendothelial system, greater accumulation in tumor cells, and improved therapeutic efficacy were observed. Therefore, this new system can deliver siRNA selectively and efficiently, and it is a promising therapeutic candidate for precise tumor-targeted therapy.
Topics & Concepts
LiposomeMononuclear phagocyte systemSmall interfering RNAMacrophageIn vitroApoptosisCancer researchCellChemistryPeptideCell-penetrating peptideRNA interferenceCell biologyTransfectionBiologyRNAImmunologyBiochemistryGeneRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesNanoparticle-Based Drug Delivery