Modular barcode beads for microfluidic single cell genomics
Cyrille L. Delley, Adam R. Abate
Abstract
Barcode beads allow efficient nucleic acid tagging in single cell genomics. Current barcode designs, however, are fabricated with a particular application in mind. Repurposing to novel targets, or altering to add additional targets as information is obtained is possible but the result is suboptimal. Here, we describe a modular framework that simplifies generation of multifunctional beads and allows their easy extension to new targets.
Topics & Concepts
BarcodeModular designComputer scienceRepurposingMicrofluidicsGenomicsNucleic acidComputational biologyNanotechnologyBiologyGenomeMaterials scienceProgramming languageGeneticsGeneEcologyOperating systemAdvanced biosensing and bioanalysis techniquesSingle-cell and spatial transcriptomicsInnovative Microfluidic and Catalytic Techniques Innovation