Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses
Huimin Zhang, Rohit R. Jadhav, Wenqiang Cao, Isabel N. Goronzy, Tuantuan Zhao, Jun Jin, Shozo Ohtsuki, Zhao‐Lan Hu, José Morales, William J. Greenleaf, Cornelia M. Weyand, Jörg J. Goronzy
Topics & Concepts
FOXP3BiologyIL-2 receptorT-cell receptorCell biologyNaive T cellT cellEpigenomeEffectorCytotoxic T cellCD8ImmunologyInflammationImmune systemGene expressionDNA methylationGeneticsGeneIn vitroImmune Cell Function and InteractionT-cell and B-cell ImmunologySingle-cell and spatial transcriptomics