Antifungal Susceptibility Testing of <i>Aspergillus niger</i> on Silicon Microwells by Intensity-Based Reflectometric Interference Spectroscopy
Christopher Heuer, Heidi Leonard, Nadav Nitzan, Ariella Lavy-Alperovitch, Naama Massad‐Ivanir, Thomas Scheper, Ester Segal
Abstract
as a model fungal pathogen, we can determine the minimal inhibitory concentration of clinically relevant antifungals within 12 h. This assay allows for expedited detection of fungal growth and provides a label-free alternative to broth microdilution and agar diffusion methods, with the potential to be used for point-of-care diagnostics.
Topics & Concepts
Aspergillus nigerAntifungalInterference (communication)Intensity (physics)SpectroscopyLight intensityMicrobiologyBiologyMedicineMaterials scienceBiotechnologyOpticsComputer sciencePhysicsTelecommunicationsChannel (broadcasting)Quantum mechanicsBiosensors and Analytical DetectionListeria monocytogenes in Food SafetyIndoor Air Quality and Microbial Exposure