Biglycan protects human neuroblastoma cells from nitric oxide-induced death by inhibiting AMPK-mTOR mediated autophagy and intracellular ROS level
Sujuan Chen, Dandan Guo, Bing‐Bing Lei, Jiajia Bi, Hai‐Jie Yang
Topics & Concepts
AutophagyAMPKBiglycanCell biologyPI3K/AKT/mTOR pathwayNeurodegenerationIntracellularProgrammed cell deathChemistryNeurotoxicityNeuroprotectionNitric oxideReactive oxygen speciesProtein kinase BApoptosisSignal transductionBiologyBiochemistryPharmacologyProtein kinase AKinaseMedicineDecorinInternal medicineDiseaseProteoglycanExtracellular matrixToxicityOrganic chemistryAutophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseProteoglycans and glycosaminoglycans research