Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women
Guilherme da Silva Rodrigues, Natália Yumi Noronha, Mariana Luciano de Almeida, Andressa Crystine da Silva Sobrinho, Lígia Moriguchi Watanabe, Marcela Augusta de Souza Pinhel, João Gabriel Ribeiro de Lima, Ren Zhang, Carla Barbosa Nonino, Christiano R. R. Alves, Carlos Roberto Bueno Júnior
Abstract
We have shown that exercise training lowers blood pressure and triglyceride levels, improves physical performance, and improves quality of life in middle-aged and elderly women. Regarding epigenetic data, we noticed that more than 800 sites are differentially methylated in whole blood after physical training. We emphasize that the differentially methylated sites in the promoter region are more hypermethylated after physical training. In addition, this study shows that key members of metabolic pathways, including AMPK signaling, TGF-β signaling, and insulin signaling, are among the genes hypermethylated after physical exercise in older women.