<i>In Vitro</i> Activity of Ertapenem against Neisseria gonorrhoeae Clinical Isolates with Decreased Susceptibility or Resistance to Extended-Spectrum Cephalosporins in Nanjing, China (2013 to 2019)
Xuechun Li, Wenjing Le, Xiangdi Lou, Caroline A. Genco, Peter A. Rice, Xiaohong Su
Abstract
Neisseria gonorrhoeae isolates collected in Nanjing, China, that possessed decreased susceptibility (or resistance) to extended-spectrum cephalosporins (ESCs) were examined for susceptibility to ertapenem, and their sequence types were determined. Ceftriaxone and cefixime MICs of ≥0.125 mg/L and ≥0.25 mg/L, respectively, were first determined in 259 strains isolated between 2013 and 2019, and then MICs of ertapenem were measured using the antimicrobial gradient Epsilometer test (Etest).
Topics & Concepts
ErtapenemCefiximeNeisseria gonorrhoeaeCephalosporinEtestMicrobiologyCeftriaxoneBiologyAntibioticsMedicineAntibiotic resistanceMeropenemReproductive tract infections researchBacterial Infections and VaccinesStreptococcal Infections and Treatments