The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion
Sergiy Sukhanov, Yusuke Higashi, Tadashi Yoshida, Srinivas Mummidi, Annayya R. Aroor, Jacob J. Russell, Shawn B. Bender, Vincent G. DeMarco, Bysani Chandrasekar
Topics & Concepts
Proinflammatory cytokineCell biologyOxidative stressSecretionEMPACytokineCell growthEmpagliflozinInflammationBiologyChemistryEndocrinologyImmunologyBiochemistryDiabetes mellitusType 2 Diabetes MellitusElectron microprobeMineralogyHelicobacter pylori-related gastroenterology studiesNeutrophil, Myeloperoxidase and Oxidative MechanismsInflammasome and immune disorders