New quinazoline sulfonamide derivatives as potential anticancer agents: Identifying a promising hit with dual EGFR/VEGFR-2 inhibitory and radiosensitizing activity
Mostafa M. Ghorab, Aiten M. Soliman, Khaled El‐Adl, Noura S. Hanafy
Topics & Concepts
ChemistryCytotoxicityQuinazolineMTT assayCell cultureDocking (animal)Cell cycle checkpointA549 cellApoptosisIC50PharmacologyEGFR inhibitorsCancer cellReceptorCell cycleIn vitroEpidermal growth factor receptorBiochemistryStereochemistryCancerBiologyGeneticsMedicineNursingQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCancer therapeutics and mechanisms