Unmasking the biological function and regulatory mechanism of NOC2L: a novel inhibitor of histone acetyltransferase
Siyi Lu, Kai Chen, Zhenzhen Liu, Zhentao Liu
Abstract
NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). NOC2L is found to have two INHAT function domains and regulates histone acetylation in a histone deacetylases (HDAC) independent manner, which is distinct from other INHATs. In this review, we summarize the biological function of NOC2L in histone acetylation regulation, P53-mediated transcription, ribosome RNA processing, certain development events and carcinogenesis. We propose that NOC2L may be explored as a potential biomarker and a therapeutic target in clinical practice.
Topics & Concepts
Histone acetyltransferaseHistoneAcetylationHDAC11Histone H2AAcetyltransferaseBiologyHistone deacetylase 5Histone deacetylase 2Histone methyltransferaseCell biologyRepressorComputational biologyHistone deacetylaseCancer researchGeneticsTranscription factorGeneHistone Deacetylase Inhibitors ResearchEpigenetics and DNA MethylationFOXO transcription factor regulation