Novel chiral matrine derivatives as potential antitumor agents: Design, synthesis and biological evaluation
Gan Qiu, Fan Li, Jamal A.H. Kowah, Junwei Xie, Qingfeng Long, Lisheng Wang, Xu Liu
Topics & Concepts
MatrineChemistryPharmacologyIn vivoIC50Docking (animal)CytotoxicityApoptosisCancer cellPaclitaxelToxicityNatural productIn vitroStereochemistryBiochemistryCancerBiologyMedicineInternal medicineBiotechnologyNursingChromatographyOrganic chemistryCancer therapeutics and mechanismsHIV/AIDS drug development and treatmentCalcium signaling and nucleotide metabolism