Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury
Zhiyan Qin, Gengyi Zhang, Shiqin Jiang, Fangqing Ning, Zhongxiang Zhao, Min Huang, Jing Jin
Topics & Concepts
Tripterygium wilfordiiDownregulation and upregulationTranscriptomeGPX4MetabolomicsBiologyWestern blotReproductive toxicityLipid peroxidationOxidative stressToxicityAndrologyInternal medicinePharmacologyEndocrinologyGene expressionMedicineGeneBioinformaticsGeneticsSuperoxide dismutasePathologyGlutathione peroxidaseAlternative medicineNatural Compounds in Disease TreatmentFerroptosis and cancer prognosisGinseng Biological Effects and Applications