Synthesis and computational studies on novel thiazine-thiazole hybrid analogues as dual α-amylase and α-glucosidase inhibitors for combating diabetes mellitus
Wajid Rehman, Yousaf Khan, Thoraya A. Farghaly, Hina Sarfraz, Komal Arooj, Mahrukh Naseem
Topics & Concepts
ADMEChemistryPostprandialVirtual screeningPharmacologyIn vitroInhibitory postsynaptic potentialComputational biologyMolecular dynamicsBiochemistryCombinatorial chemistryEnzymeDocking (animal)StackingIn silicoThiazineLead compoundStructure–activity relationshipEbselenDiabetes mellitusHydrogen bondMolecular modelMetabolic stabilityProtein Data Bank (RCSB PDB)SinomenineNatural Antidiabetic Agents StudiesCarbohydrate Chemistry and SynthesisDiet, Metabolism, and Disease