Possible high risk of transmission of the Nipah virus in South and South East Asia: a review
Jagadish Joshi, Yogendra Shah, Kishor Pandey, Ram Prashad Ojha, Chet Raj Joshi, Lok Raj Bhatt, Shyam Prakash Dumre, Pushpa Raj Acharya, Hem Raj Joshi, Shikha Rimal, Ramesh Shahi, Deepak Pokharel, Kamal Singh Khadka, Bimal Dahal, Saroj Nepal, Ram Singh Dhami, Krishna Prasad Pant, Rajdip Basnet, Basu Dev Pandey
Abstract
Nipah virus (NiV) is a zoonotic, single-stranded RNA virus from the family Paramyxoviridae, genus Henipavirus. NiV is a biosafety-level-4 pathogen that is mostly spread by Pteropus species, which serve as its natural reservoir host. NiV is one of the major public health challenges in South and South East Asia. However, few molecular studies have been conducted to characterise NiV in a specific region. The main objective of this review is to understand the epidemiology, pathogenesis, molecular surveillance, transmission dynamics, genetic diversity, reservoir host, clinical characteristics, and phylogenetics of NiV. South and South East Asian nations have experienced NiV outbreaks. Phylogenetic analysis confirmed that two primary clades of NiV are in circulation. In humans, NiV causes severe respiratory illness and/or deadly encephalitis. NiV is mainly diagnosed by ELISA along with PCR. Therefore, we recommend that the governments of the region support the One Health approach to reducing the risk of zoonotic disease transmission in their respective countries.